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Index > Protein center > Lipe(Gene name) > Rat
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  • Lipe (Gene name),
  • Hormone-sensitive lipase (Protein name ),  LIPS_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Lipe;
    Protein name:
    Hormone-sensitive lipase(HSL);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with PTRF in the adipocyte cytoplasm.
    Function:
    In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
    Subcellular Location:
    Cell membrane Membrane caveola Cytoplasm cytosol Found in the high-density caveolae (By similarity). Translocates to the cytoplasm from the caveolae upon insulin stimulation.
    Protein Attributes:
    Sequence length:
    1068
    Sequence:
    50:
    MKPRRPISFT | REITAMEPSS | TSVSRPEWRP | EAQQTLTDYP | GSRELQEFGI | 
    100:
    PQKQSLPNEA | TAQQGAEFQQ | EQGVQQSTLL | QKLLTPLAFP | VPQQSFPSHK | 
    150:
    VHSDQQEATS | QNGPGAGKVH | TTQKELEHRD | EHVGTAESGP | AEPPPATEVE | 
    200:
    ATSIAQAVSG | PDKKLPTQTD | LVSQERAEQS | DPTAQQTPLV | QGVKSDQGSL | 
    250:
    IESGILARLQ | KLAIQQPSQE | WKTFLDCVTE | SDMEKYLNSS | SKSNPPEPSG | 
    300:
    GTVIPGTLPS | KQKPDCGKMS | GYGGKLPHGK | KGILQKHKHY | WDTASAFSHS | 
    350:
    MDLRTMTQSL | VALAEDNMAF | FSSQGPGETA | RRLSNVFAGV | REQALGLEPT | 
    400:
    LGQLLGVAHH | FDLDTETPAN | GYRSLVHTAR | CCLAHLLHKS | RYVASNRRSI | 
    450:
    FFRASHNLAE | LEAYLAALTQ | LRALAYYAQR | LLTINRPGVL | FFEGDEGLSA | 
    500:
    DFLQDYVTLH | KGCFYGRCLG | FQFTPAIRPF | LQTLSIGLVS | FGEHYKRNET | 
    550:
    GLSVTASSLF | TGGRFAIDPE | LRGAEFERII | QNLDVHFWKA | FWNITEIEVL | 
    600:
    SSLANMASTT | VRVSRLLSLP | PEAFEMPLTS | DPKLTVTISP | PLAHTGPGPV | 
    650:
    LARLISYDLR | EGQDSKMLNS | LAKSEGPRLE | LRPRPQQAPR | SRALVVHIHG | 
    700:
    GGFVAQTSKS | HEPYLKNWAQ | ELGVPIISID | YSLAPEAPFP | RALEECFFAY | 
    750:
    CWAVKHCELL | GSTGERICLA | GDSAGGNLCI | TVSLRAAAYG | VRVPDGIMAA | 
    800:
    YPVTTLQSSA | SPSRLLSLMD | PLLPLSVLSK | CVSAYSGTET | EDHFDSDQKA | 
    850:
    LGVMGLVQRD | TSLFLRDLRL | GASSWLNSFL | ELSGRKPHKT | PLPATETLRP | 
    900:
    TDSGRLTESM | RRSVSEAALA | QPEGLLGTDS | LKKLTIKDLS | FKGNSEPSDS | 
    950:
    PEMSQSMETL | GPSTPSDVNF | FLRSGNSQEE | AETRDDISPM | DGIPRVRAAF | 
    1000:
    PDGFHPRRSS | QGVLHMPLYS | SPIVKNPFMS | PLLAPDVMLK | TLPPVHLVAC | 
    1050:
    ALDPMLDDSV | MFARRLKDLG | QPVTLKVVED | LPHGFLSLAA | LCRETRQAAE | 
    1068:
    LCVQRIRLIL | TPPAAPLT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat HSL
    Cat.:
    E1276m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat HSL
    Cat.:
    E1276r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat HSL
    Cat.:
    E1276b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat HSL
    Cat.:
    E1276h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat HSL
    Cat.:
    E1276p
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat HSL
    Cat.:
    U1276p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat HSL
    Cat.:
    U1276r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat HSL
    Cat.:
    U1276h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat HSL
    Cat.:
    U1276m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat HSL
    Cat.:
    U1276b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat HSL
    Polyclonal Antibody for Rat HSL
    Polyclonal Antibody for Rat HSL
    Cat.:
    P1276Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat HSL
    Cat.:
    P1276Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat HSL
    Cat.:
    P1276Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat HSL
    Monoclonal Antibody for Rat HSL
    Monoclonal Antibody for Rat HSL
    Monoclonal Antibody for Rat HSL
    Monoclonal Antibody for Rat HSL
    Protein for Rat HSL
    Protein for Rat HSL
    Protein for Rat HSL
    Protein for Rat HSL
    Protein for Rat HSL

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    References
    1. 1.
      "Nucleotide sequence of rat adipose hormone sensitive lipase cDNA."
      Holm C. , Kirchgessner T.G. , Svenson K.L. , Lusis A.J. , Belfrage P. , Schotz M.C.
      Nucleic Acids Res.16:9879-9879(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Adipose tissue.
    2. 2.
      "Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3."
      Holm C. , Kirchgessner T.G. , Svenson K.L. , Fredrikson G. , Nilsson S. , Miller C.G. , Shively J.E. , Heinzmann C. , Sparkes R.S. , Mohandas T. , Lusis A.J. , Belfrage P. , Schotz M.C.
      Science241:1503-1506(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Adipose tissue.
    3. 3.
      Holm C.
      Submitted (1995-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 842-855 AND 1046-1068
    4. 4.
      "Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase."
      Holst L.S. , Langin D. , Mulder H. , Laurell H. , Grober J. , Bergh A. , Mohrenweiser H.W. , Edgren G. , Holm C.
      Genomics35:441-447(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: Sprague-Dawley.
      tissue: Testis.
    5. 5.
      "Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro."
      Anthonsen M.W. , Roennstrand L. , Wernstedt C. , Degerman E. , Holm C.
      J. Biol. Chem.273:215-221(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-863; SER-959 AND SER-960;MUTAGENESIS OF SER-863; SER-865; SER-959 AND SER-960
    6. 6.
      "Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest and following lipolysis during adrenergic or contractile stimulation."
      Macpherson R.E. , Vandenboom R. , Roy B.D. , Peters S.J.
      Physiol. Rep.1:E00084-E00084(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIPE AND PNPLA2;PHOSPHORYLATION
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