Protein name:
Hormone-sensitive lipase (HSL) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with PTRF in the adipocyte cytoplasm.
Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Subcellular Location:
Cell membrane
Membrane
caveola
Cytoplasm
cytosol
Found in the high-density caveolae (By similarity). Translocates to the cytoplasm from the caveolae upon insulin stimulation.
Protein Attributes:
50:
MKPRRPISFT | REITAMEPSS | TSVSRPEWRP | EAQQTLTDYP | GSRELQEFGI |
100:
PQKQSLPNEA | TAQQGAEFQQ | EQGVQQSTLL | QKLLTPLAFP | VPQQSFPSHK |
150:
VHSDQQEATS | QNGPGAGKVH | TTQKELEHRD | EHVGTAESGP | AEPPPATEVE |
200:
ATSIAQAVSG | PDKKLPTQTD | LVSQERAEQS | DPTAQQTPLV | QGVKSDQGSL |
250:
IESGILARLQ | KLAIQQPSQE | WKTFLDCVTE | SDMEKYLNSS | SKSNPPEPSG |
300:
GTVIPGTLPS | KQKPDCGKMS | GYGGKLPHGK | KGILQKHKHY | WDTASAFSHS |
350:
MDLRTMTQSL | VALAEDNMAF | FSSQGPGETA | RRLSNVFAGV | REQALGLEPT |
400:
LGQLLGVAHH | FDLDTETPAN | GYRSLVHTAR | CCLAHLLHKS | RYVASNRRSI |
450:
FFRASHNLAE | LEAYLAALTQ | LRALAYYAQR | LLTINRPGVL | FFEGDEGLSA |
500:
DFLQDYVTLH | KGCFYGRCLG | FQFTPAIRPF | LQTLSIGLVS | FGEHYKRNET |
550:
GLSVTASSLF | TGGRFAIDPE | LRGAEFERII | QNLDVHFWKA | FWNITEIEVL |
600:
SSLANMASTT | VRVSRLLSLP | PEAFEMPLTS | DPKLTVTISP | PLAHTGPGPV |
650:
LARLISYDLR | EGQDSKMLNS | LAKSEGPRLE | LRPRPQQAPR | SRALVVHIHG |
700:
GGFVAQTSKS | HEPYLKNWAQ | ELGVPIISID | YSLAPEAPFP | RALEECFFAY |
750:
CWAVKHCELL | GSTGERICLA | GDSAGGNLCI | TVSLRAAAYG | VRVPDGIMAA |
800:
YPVTTLQSSA | SPSRLLSLMD | PLLPLSVLSK | CVSAYSGTET | EDHFDSDQKA |
850:
LGVMGLVQRD | TSLFLRDLRL | GASSWLNSFL | ELSGRKPHKT | PLPATETLRP |
900:
TDSGRLTESM | RRSVSEAALA | QPEGLLGTDS | LKKLTIKDLS | FKGNSEPSDS |
950:
PEMSQSMETL | GPSTPSDVNF | FLRSGNSQEE | AETRDDISPM | DGIPRVRAAF |
1000:
PDGFHPRRSS | QGVLHMPLYS | SPIVKNPFMS | PLLAPDVMLK | TLPPVHLVAC |
1050:
ALDPMLDDSV | MFARRLKDLG | QPVTLKVVED | LPHGFLSLAA | LCRETRQAAE |
1068:
LCVQRIRLIL | TPPAAPLT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Bovine
Human
Pig
Polyclonal Antibody for Rat HSL
Polyclonal Antibody for Rat HSL
Polyclonal Antibody for Rat HSL
Polyclonal Antibody for Rat HSL
Polyclonal Antibody for Rat HSL
Monoclonal Antibody for Rat HSL
Monoclonal Antibody for Rat HSL
Monoclonal Antibody for Rat HSL
Monoclonal Antibody for Rat HSL
Monoclonal Antibody for Rat HSL
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Adipose tissue .
2.
"Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3."
Holm C.
,
Kirchgessner T.G.
,
Svenson K.L.
,
Fredrikson G.
,
Nilsson S.
,
Miller C.G.
,
Shively J.E.
,
Heinzmann C.
,
Sparkes R.S.
,
Mohandas T.
,
Lusis A.J.
,
Belfrage P.
,
Schotz M.C.
Science241:1503-1506(1988)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Adipose tissue .
3.
Holm C.
Submitted (1995-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 842-855 AND 1046-1068
4.
"Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase."
Holst L.S.
,
Langin D.
,
Mulder H.
,
Laurell H.
,
Grober J.
,
Bergh A.
,
Mohrenweiser H.W.
,
Edgren G.
,
Holm C.
Genomics35:441-447(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
Sprague-Dawley .
tissue :
Testis .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-863; SER-959 AND SER-960;MUTAGENESIS OF SER-863; SER-865; SER-959 AND SER-960
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LIPE AND PNPLA2;PHOSPHORYLATION